Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica
نویسندگان
چکیده
منابع مشابه
Lack of reversion in triclabendazole-resistant Fasciola hepatica.
RESISTANCE to triclabendazole in field isolates of the liver fluke Fasciola hepatica in sheep was described for the first time by Overend and Bowen (1995) in Australia. In Europe, resistance of F hepatica in sheep to triclabendazole has been reported in Ireland (Lane 1998), Scotland (Mitchell and others 1998), Wales (Thomas and others 2000) and the Netherlands (Moll and others 2000). On the Dut...
متن کاملApparent Triclabendazole-Resistant Human Fasciola hepatica Infection, the Netherlands
1. European Food Safety Authority. EFSA Panel on Animal Health and Welfare; scientifi c opinion on African swine fever. EFSA Journal. 2010;8:1556. http://dx.doi. org/10.2903/j.efsa.20101556 2. Sanchez-Botija C. Reservoirs of ASFV: a study of the ASFV in arthropods by means of the haemadsorption test. Bull Off Int Epizoot. 1963;60:895–9. 3. Boinas FS, Wilson AJ, Hutchings GH, Martins C, Dixon LJ...
متن کاملAn amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations.
Control of fasciolosis is threatened by the development of anthelmintic resistance. Enhanced triclabendazole (TCBZ) efflux by ABC transporters such as P-glycoprotein (Pgp) has been implicated in this process. A putative full length cDNA coding for a Pgp expressed in adult Fasciola hepatica has been constructed and used to design a primer set capable of amplifying a region encoding part of the s...
متن کاملThe synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica.
OBJECTIVES The trematocidal properties of a synthetic peroxide, 1,2,4-trioxolane (OZ78) were determined both in vivo and in vitro. METHODS Two weeks post-infection Echinostoma caproni-infected mice were administered single oral doses of 400-1000 mg/kg OZ78. Fasciola hepatica-infected rats were treated orally with 50-400 mg/kg OZ78 3 and 8-9 weeks post-infection. Worm burden reductions were as...
متن کاملConfirmation of Fasciola hepatica resistant to triclabendazole in naturally infected Australian beef and dairy cattle☆
Triclabendazole (TCBZ) is the drug of choice for Fasciola hepatica control and reports of F. hepatica resistant to this drug from a wide range of geographic regions are very concerning. This study investigated the presence of TCBZ resistance in F. hepatica in naturally infected Australian beef and dairy cattle herds and evaluated methods of measuring the levels of resistance. Faecal egg count a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Transactions of the Royal Society of Tropical Medicine and Hygiene
سال: 2007
ISSN: 0035-9203
DOI: 10.1016/j.trstmh.2007.07.012